Calvagone Experts Team

OUR SKILLS TO HELP YOU IN MODELING AND SIMULATION

Emilie Hénin

Consultant

Emilie obtained a Master in Engineering in Biosciences, Bioinformatics and Modelling from the National Institute of Applied Sciences of Lyon in 2005, and an MSc in Pharmacology and Pharmacometrics from the University of Lyon in 2005. After completing her PhD entitled “Study by modelling and simulation of the impact on efficacy and toxicity of non-compliance to oral anticancer drugs” from the University of Lyon in 2008, Emilie joined the Pharmacometrics Group from Uppsala University, as a postdoctoral fellow. Between 2011 and 2015, Emilie was a hospital-university researcher– lecturer in Pharmacology and Pharmacometrics in the University of Lyon, with projects oriented towards the characterization of the dose-response relationships and therapeutic optimization using pharmacometrics, particularly in oncology and in paediatrics. She acted as an expert in pharmacometrics within the paediatric pole of the clinical investigation centre of the hospital of Lyon. She has also trained and supervised Msc students and PhD candidates in pharmacometrics, and obtained her accreditation to supervise research in 2013. Her research has been granted by several distinctive awards, including the Lewis Sheiner Student award (PAGE 2006 as PhD candidate, and PAGE 2014 as PhD supervisor), and the AAPS Graduate Student Award (AAPS 2008). She is author and co-author of 40 research articles published in international peer-reviewed journals. Emilie lives in France in Lyon area.

Pierre-Alexandre Noguine

Consultant

Pierre-Alexandre obtained a Technical degree in Biophysics from E.T.S.L (Ecole Technique Supérieure du Laboratoire) Paris in 1989 followed by post graduate training in Biology, Mathematics and Statistics from C.N.A.M (Conservatoire National des Arts et Métiers) Paris in 1990. Pierre-Alexandre joined Servier Laboratories in 1990 where he started as a Data Manager on Clintrial and later was involved of SAS outputs for clinical reports. In 1997, Pierre-Alexandre joined the QA department at Servier where he was in charge of GCP IT audits. In 2004, he joined the Pharmacokinetic department in the same company as an IT Project Leader involved of SAS programs, data extractions, validation and administration of NONMEM and WINNONLIN. Pierre-Alexandre worked at Exprimo from 2009-2015 as consultant in charge of programming with SAS, R and Visual Studio. Pierre-Alexandre lives in France in Paris area.

Philippe Pierrillas

Junior Consultant

Philippe obtained his PharmD degree from the University of Marseille in 2012 and his MSc in Pharmacology and Pharmacometrics from the University of Toulouse in 2012. During his PhD, that he got from the University of Lyon in 2016, Philippe worked on the development of interspecies translational approaches using semi-mechanistic pharmacokinetic-pharmacodynamic (PK-PD) models and PBPK (Physiologically-based pharmacokinetics) modelling to improve the clinical development of anticancer drugs. Directly after his PhD, Philippe joined the Pharmacometrics Research Group from Uppsala University (Sweden) as a postdoctoral researcher, where he focused on the application of model-based adaptive optimal design to improve the dose finding strategy of clinical trials involving combination therapy. Philippe lives in France in Lyon area.

Erno Van Schaick

Senior Consultant

Erno obtained a M.Sc. in Bio-pharmaceutical Sciences from Leiden University, the Netherlands in 1992 and obtained his PhD from Leiden University in 1997. The emphasis of his PhD research, a collaboration with Glaxo (now GSK) in the UK, was on the application of mechanism-based PK/PD modelling to assess the in vivo selectivity of novel purinergic drugs. In 1996 Erno joined the department of clinical pharmacokinetics at J&J in Belgium supporting clinical development programs of CNS compounds and global pharmacometric strategies for novel antidepressants and anxiolytics. From 2000 Erno worked in early clinical development, where he developed an interest in the application of translational pharmacometric approaches to facilitate transfer of compounds from animal to man. In 2003, he joined Tibotec/Virco as clinical pharmacologist with the aim to develop of population PK(/PD) approaches to guide personalized HIV-therapy. From 2004 onwards Erno worked as senior consultant at Exprimo specializing in the implementation of modelling and simulation in drug development and as managing director of Exprimo in 2015-2106. Erno is author of several research papers on the application of pharmacokinetic-pharmacodynamic modelling and mixed effects analyses. Erno lives in The Netherlands.

Christian Laveille

Director

Christian obtained his Pharm.D. degree from the University of Lyon in 1985 with a specialization in pharmacokinetics, pharmacology and Toxicology in 1986. Christian joined Servier in 1989 where he started as a pharmacokineticist. In 1991 he moved to the University of California, San Francisco, for a training period where he studied both the methodological and practical aspects of utilizing mixed effects modelling. He returned to France in 1992 and started to implement mixed effects modelling within Servier. Christian held several posts within the Division of Pharmacokinetics, which involved population PK/PD analysis for a variety of compounds in a range of therapeutic classes (endocrinology, CNS, cardiovascular). In the last one and a half years, he was responsible for the Clinical Pharmacokinetics Department at Servier. Christian subsequently worked at Exprimo from 2005-2015 as senior consultant and then from the last year as Scientific Director, hugely expanding his modelling and simulation expertise. He has more than 25 years of drug development experience within the pharmaceutical industry and has also contributed to several registration dossiers for new drug applications. Christian is (co) author of several papers in the field of pharmacokinetics and pharmacodynamics. Christian lives in France in Lyon area.